The language of magnitude comparison.

When 2 objects differ in magnitude, their relation can be described with a "smaller" comparative (e.g., less, shorter, lower) or a "larger" comparative (e.g., more, taller, higher). We show that, across multiple dimensions and tasks, English speakers preferentially use the latter. In sentence completion tasks, this higher use of larger comparatives (HULC) effect is more pronounced when the larger item is presented on the left (for simultaneous presentation) or second (for sequential presentation). The HULC effect is not diminished by making the 2 items more similar, but it is somewhat lessened when both objects are of low magnitude. These results illuminate the processes underlying the judgment and representation of relative magnitudes.This is the accepted manuscript. This article may not exactly replicate the final version published in the APA journal. It is not the copy of record. The final version is available from APA at http://psycnet.apa.org/journals/xge/143/2/510/. ©2014 American Psychological Associatio

The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity

BackgroundThe outcome of a viral infection is regulated by complex interactions of viral and host factors. SARS coronavirus (SARS-CoV) engages and regulates several innate immune response pathways during infection. We have previously shown that the SARS-CoV Papain-like Protease (PLpro) inhibits type I interferon (IFN) by inhibiting IRF3 phosphorylation thereby blocking downstream Interferon induction. This finding prompted us to identify other potential mechanisms of inhibition of PLpro on IFN induction.Methods We have used plasmids expressing PLpro and IRF3 including an IRF3 mutant that is constitutively active, called IRF3(5D). In these experiments we utilize transfections, chromatin immunoprecipitation, Electro-mobility Shift Assays (EMSA) and protein localization to identify where IRF3 and IRF3(5D) are inhibited by PLpro.ResultsHere we show that PLpro also inhibits IRF3 activation at a step after phosphorylation and that this inhibition is dependent on the de-ubiquitination (DUB) activity of PLpro. We found that PLpro is able to block the type I IFN induction of a constitutively active IRF3, but does not inhibit IRF3 dimerization, nuclear localization or DNA binding. However, inhibition of PLpro’s DUB activity by mutagenesis blocked the IRF3 inhibition activity of PLpro, suggesting a role for IRF3 ubiquitination in induction of a type I IFN innate immune response.ConclusionThese results demonstrate an additional mechanism that PLpro is able to inhibit IRF3 signaling. These data suggest novel innate immune antagonism activities of PLpro that may contribute to SARS-CoV pathogenesis

North American Genetic Counselors\u27 Approach to Collecting and Using Ancestry in Clinical Practice

Current guidelines from the National Society of Genetic Counselors (NSGC) recommend that patients\u27 ancestry be obtained when taking a family history. However, no study has explored how consistently genetic counselors obtain or utilize this information. The goals of this study included assessing how genetic counselors collect their patients\u27 ancestry, what factors influence this decision, and how they view the utility of this information. Genetic counselors working in a direct patient care setting in the US or Canada were recruited to participate in an anonymous survey via an NSGC email blast. Most participants (n = 115) obtain information about their patients\u27 ancestry (96.5%), with the most common methods being directly asking the patient (91%) and utilizing intake forms (43.2%). Of participants who ask about ancestry directly, 50.5% always ask about the presence of Ashkenazi Jewish ancestry and 70.3% always ask about additional ancestries, suggesting that for most genetic counselors’ collection of ancestry is standard practice. However, the clinical utility of ancestry information is highly variable, with the impact on genetic testing choice being particularly low. A slight majority of participants support a reevaluation of current ancestry guidelines (51.3%), with many participants suggesting that the varying utility of ancestry in different clinical indications/specialties should be incorporated into guidelines. Despite being standard practice for most genetic counselors, no unified approach or standard for how ancestral information should be used in genetic counseling practice was identified

A Psychometric Assessment of OCB: Clarifying the Distinction Between OCB and CWB and Developing a Revised OCB Measure

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. This study was performed to (1) assess the appropriateness of using negatively worded items in organizational citizenship behavior (OCB) scales, (2) psychometrically demonstrate the construct distinctness of OCB and counterproductive work behavior (CWB), and (3) report on a revised, short-form OCB scale. Leveraging classical test theory (CTT) and item response theory (IRT), we demonstrate that the negatively worded items from a popular OCB scale (Williams and Anderson 1991) do not measure OCB, but rather a unique construct (CWB). CTT analyses (factor analyses) indicate that the negatively worded items load onto a unique factor when the scale is analyzed on its own and load onto a CWB factor when the scale is analyzed with a CWB scale. Additionally, IRT analyses indicate that the negatively worded items exhibit lower discrimination parameters and higher levels of local independence than the positively worded items, and similar discrimination parameters and levels of local independence as the CWB items. In turn, IRT analyses were used to identify the best items from the OCB scale to create a revised, short-form scale. The short-form scale showed comparable or improved convergent and discriminant validity and internal consistency reliability, as well as similar patterns of psychometric information yielded from IRT analyses, compared to the original scale. In short, the revised measure better aligns with conceptual definitions of OCB, demonstrates acceptable psychometric characteristics, and, given its reduced length, is of more practical value to researchers wishing to assess this construct within different types of research designs (e.g., longitudinal, multi-source)

Leading When Overweight: the Influence of Supervisor Body Weight on Subordinates’ Perceptions and Citizenship Behaviors

Integrating the stereotype content model, attribution theory, and social exchange theory, we examined the perceptions underlying bias towards overweight supervisors and the effect of supervisor weight on the workplace behaviors of subordinates. Study 1 (N = 204) confirmed that supervisors are subject to weight bias, such that supervisor weight is negatively related to subordinates’ perceptions of supervisor competence. In turn, Study 2 (N = 829) and Study 3 (N = 226) demonstrated that supervisor weight indirectly influences subordinates’ perceptions of the subordinate-supervisor relationship (leader-member exchange) and important reciprocal workplace behaviors (organizational citizenship behaviors). Furthermore, in predicting perceptions of competence, we found no interaction between supervisor weight and supervisor status, subordinate weight, or supervisor gender. We also found that supervisor weight does not influence perceptions of supervisor warmth and that the relationship between supervisor weight and perceptions of supervisor competence is linear

The Temporal Dynamics Between Work Stressors And Health Behaviors

Applying dynamic equilibrium theory (DET), we examined the temporal dynamics between role overload and three health behaviors (sleep, diet, physical activity). Participants (N = 781) completed five surveys, with 1-month lag between assessments, and the data were analyzed using general cross-lagged panel modeling (GCLM). Results indicated that people had stable health behavior patterns (i.e., there were strong unit effects) that were related to stable role overload patterns (i.e., the chronic role overload and health behavior factors were significantly related). Furthermore, while monthly increases (impulses) in role overload had a negative effect on health behaviors concurrently, health behaviors quickly adapted or regressed back toward previous levels (i.e., there were weak autoregressive and cross-lagged effects after accounting for chronic factors). Impulse response functions were created to show the specific proportion of the initial impulse effect that persisted on each health behavior over time. The results of these response functions indicated that diet and physical activity regressed back to previous levels within 1 month, whereas sleep regressed back to previous levels within 2 months. Collectively, our results suggest that people engage in fairly stable patterns of health behaviors and that these patterns are partly determined by chronic role overload. Our results also suggest that people are generally resilient to temporary changes in role overload, such that the resulting immediate changes in behavior do not persist or become habitual. These results underscore the strength of habits and the resistance to health behavior change, as well as provide support for the use of GCLM for studying DET